Enemion biternatum has been mistaken for the superficially similar Thalictrum thalictroides because of its white flowers and compound Thalictrum-like leaves. Enemion biternatum is easily distinguished, however, by its few-seeded follicles and deeply lobed leaves with glandular-apiculate apices. Thalictrum thalictroides, on the other hand, is characterized by having achenes and somewhat crenate leaves with notched apices.